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Dishonored Wiki
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Note off neutral is

This note is found on the left side of the desk in the ruined offices at the end of the east wing, on the second floor of the Addermire Institute, it opens the safe at the back containing a Silver Ingot and the Combat Sleep Dart Formula blueprints. The second safe in the same room requires no combination.

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Some of Doctor Hypatia's odder patients are occasionally carrying items that are hard to classify for storage. So I've put them in the office safe, off to the side of the main entryway. The combination is a random 3-digit combination.


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